Top 5 Pet Stain Removers For Mattress: Expert Review

That sudden, unmistakable wet spot appears on your mattress. Your heart sinks. You love your furry friend, but accidents happen, and cleaning them up feels like a battle you can never truly win. Dealing with pet stains on a mattress is frustrating. You worry about lingering odors, stubborn discoloration, and whether the cleaning product you choose will actually work or just make things worse.

Choosing the right pet stain remover for your mattress feels overwhelming. Should you use a store-bought spray, a DIY vinegar solution, or something enzyme-based? Many products promise miracles but leave behind sticky residue or fail to eliminate the deep-set urine smell. You need a solution that is safe for your mattress fabric but tough enough for pet accidents.

This guide cuts through the confusion. We will explore the best methods and products designed specifically to tackle tough pet stains and odors on mattresses. Keep reading to learn exactly what ingredients to look for, how to apply them correctly, and how to restore your mattress to a fresh, clean state. Let’s get your sleep sanctuary smelling fresh again!

Top Pet Stain Remover For Mattress Recommendations

No. 1
Rocco & Roxie Supply Co. Stain & Strong Odor Eliminator, Enzyme Cleaner, Pet Odor Eliminator for Home - Carpet Stain Remover for Cats & Dog Pee - Urine Destroyer - Carpet Cleaner Spray Clear, 32 Fl Oz
  • Certified Gentle & Safe Pet Carpet Cleaner Solution: Chlorine free, color safe, no hazardous propellants or residue; safe to use around pets and children; certified safe for all carpets with a Seal of Approval by the Carpet and Rug Institute (CRI)
  • Pet Enzyme Carpet Cleaner for Stains, Odors, Residue: If it's gross, it's gone; the stain and the stink; from stinky yellow pet urine, feces to vomit or other organic spills, Rocco & Roxie professional strength stain & odor eliminator tackles it all
  • Cat & Dog Urine Enzyme Cleaner for Every Surface, Every Time: For use on carpets, floors, furniture, clothing, litter boxes, kennels, carriers, all pet living and sleeping areas—anywhere stains happen enzyme cleaner for dog urine
  • Cat & Dog Urine Enzyme Cleaner for Every Surface, Every Time: For use on carpets, floors, furniture, clothing, litter boxes, kennels, carriers, all pet living and sleeping areas—anywhere stains happen enzyme cleaner for dog urine
  • Buy With Confidence: You want the best for your best friend; we do, too; if you are not satisfied with the performance of this Rocco & Roxie stain & odor eliminator, contact us; we are determined to make it rightx
No. 2
Resolve Ultra Pet Carpet Cleaner Spray – for Removal of Pet Stains & Odors, 32oz
  • 1. DESTROYS STUBBORN STAINS THE FIRST TIME Penetrates deep to lift and remove tough pet stains like feces, vomit, dirt and their odors
  • 2. HELPS PREVENT REMARKING Discourages pets from returning to make a mess in the same spot
  • 3. OXI+ODOR STOP TECHNOLOGY Removes odors and leaves your home smelling fresh.
  • 4. SAFE FOR ALL SOFT SURFACE AREAS Effective of carpets, upholstery, and area rugs for versatile cleaning.
  • 5. FROM THE #1 PET MESS CLEANING BRAND*: Trusted by pet owners for superior cleaning performance. *Based on unit sales of pet mess cleaning products ending latest 52 weeks 6/15/24
No. 3
Resolve Urine Destroyer Spray – Pet Stain and Odor Remover, Carpet Cleaner Solution for Cat and Dog Urine, 32 Fl Oz
  • 1. DESTROYS URINE ODORS THE FIRST TIME Urine elimination technology neutralizes and removes odors on contact for immediate freshness
  • 2. REMOVES PET STAINS AND MORE Penetrates deep to lift and remove tough pet stains like feces, vomit, dirt and their odors
  • 3. HELPS PREVENT REMARKING Discourages pets from returning to make a mess in the same spot
  • 4. SAFE FOR ALL SOFT SURFACE AREAS Effective of carpets, upholstery, and area rugs for versatile cleaning.
  • 5. FROM THE #1 PET MESS CLEANING BRAND*: Trusted by pet owners for superior cleaning performance. *Based on unit sales of pet mess cleaning products ending latest 52 weeks 6/15/24
No. 4
Rocco & Roxie Extreme Stain & Odor Eliminator for Strong Odor, Pet Urine Enzyme Cleaner Destroyer, Stain Remover, Dog Poop and Cat Pee, Enzymatic Carpet Cleaner Spray for Home, Puppy Potty Training
  • Eliminates Stains, Odors, & Residue: If it’s gross, it’s gone; from blowouts, urine, vomit, and other organic spills; Rocco & Roxie stain & odor eliminator has a subtle Meyer lemon scent that quickly dissipates, leaving your space feeling fresher
  • Every Surface, Every Time: Our fast-acting carpet stain remover spray formula works great on floors, furniture, clothing, pet bedding, litter boxes, travel crates, hamster cages, cars, campers, and anywhere else major accidents happen
  • Minerals & Enzymes: The key is getting to the problem deep-down, so we added a mineral-based odor neutralizer to our bio-enzymatic formula; upon contact with tough stains & odors, this pet enzyme cleaner feasts on ammonia crystals and organic matter
  • Gentle & Safe Carpet Spray: Safe to use around pets and children, when used as directed; chlorine-free, color-safe with no hazardous propellants; Certified Safe for all carpets with the Seal of Approval by the trusted Carpet and Rug Institute (CRI)
  • Buy With Confidence: You want the best for your best friend; we do, too; if you are not satisfied with the performance of this pet odor eliminator and stain remover, contact us; we are determined to make it right
No. 5
Resolve Pet Expert Stain and Odor Remover, Carpet Cleaner, Pet Stain and Odor Remover, Carpet & Upholstery Cleaner - Removes Stains and Odors, 22 oz
  • 1. DESTROYS URINE ODORS THE FIRST TIME Urine elimination technology neutralizes and removes odors on contact for immediate freshness
  • 2. REMOVES PET STAINS AND MORE Penetrates deep to lift and remove tough pet stains like feces, vomit, dirt and their odors
  • 3. HELPS PREVENT REMARKING Discourages pets from returning to make a mess in the same spot
  • 4. SAFE FOR ALL SOFT SURFACE AREAS Effective of carpets, upholstery, and area rugs for versatile cleaning.
  • 5. FROM THE #1 PET MESS CLEANING BRAND*: Trusted by pet owners for superior cleaning performance. *Based on unit sales of pet mess cleaning products ending latest 52 weeks 6/15/24
No. 6
Pet Odor and Stain Eliminator - 32 oz ACTIVE Enzyme Cleaner for Dog & Cat Urine, Stain Remover Spray for Carpet, Upholstery, Hardwood, Spot Cleaning, Deodorizer for Dogs Cats Pets - Natural Citrus Oil
  • Completely Eliminate Odors & Stains: Our ready-to-use Advanced Pet Odor Eliminator Sprays target the source of animal messes, Lifting Stains and Removing Smells, leaving behind only a Pleasant Citrus Oil Scent! Compare to other products that only mask the problem instead of actually deodorizing
  • Bio Enzymatic Odor Destroyer: ACTIVE Pet Stain and Odor Remover Formula is specially made with Enzymes and Natural Probiotics that Remove Smell from Puppy Accidents, Cat Urine, and all odour from Pee, Poop, Vomit, Litter and more
  • Professional Stain Removal: ACTIVE Enzyme Cleaners will easily get rid of mess and set-in stains in Carpets, Fabric, Floor. Our powerful Stain Eliminating Solution creates a Deep Cleaning Lather with every Spray for full Stain Treatment
  • Designed for Home Surfaces: Universal Indoor Pet Clean-up Spray for couch stains, Wood Floors, Rug, Furniture, Mattress, Dog bed, Kennel- wherever your pet goes! Get any hard to clean accident in the house with ACTIVE deodorizers and animal stain removers
  • Proudly Made in USA: ACTIVE Pet Odor Neutralizer Spray is made entirely in the United States with just the best components and ingredients. Our Formula is gentle yet Effective, and Safe to use around Pets and Kids
No. 7
CloroxPro Urine Remover for Stains and Odors Spray, 32 Ounces (Package May Vary)
  • STAIN AND ODOR REMOVER: Clorox Urine Remover for Stains and Odors breaks down urine to eliminate odor, not mask it, while the powerful hydrogen peroxide cleaner removes stains
  • URINE CLEANER: Formula uses hydrogen peroxide to remove uric acid crystals and break down the cell structure of bacteria to eliminate the lingering smell and evidence of urine
  • CARPET STAIN REMOVER: This powerful stain remover is safe to use on fibers and soft surfaces such as carpet upholstery mattresses and bed linens, as well as hard to clean surfaces such as grout
  • OUTDOOR STAIN REMOVER: The hydrogen peroxide formula works great on hard non-porous surfaces such as concrete sidewalks, outdoor tile and trash areas
  • GREAT FOR COMMERCIAL USE: From CloroxPro, this urine remover eliminates the smell and appearance of urine in schools, restaurants, bars, hotels, outdoor stadiums and more
No. 8
Rocco & Roxie Oxy Stain Remover - Oxygen Powered Carpet Cleaner Spray - Pet Stain Remover for Carpet, Spot Cleaner for Upholstery, Couch, Laundry, Rug, Clothes, Car Seat, Mattress, Sofa, and More
  • Fast Acting Carpet Stain Remover – Activated Oxygen technology breaks up stains right before your eyes. Eliminates stains at the source so they never come back
  • Tough Professional Carpet Cleaner – Our Professional Strength Oxy carpet cleaner spray formula removes tough set-in stains caused by urine, feces, vomit, blood, dirt, grass, juice, chocolate, coffee, tea, tomato sauce, ink, red wine and more
  • Gentle – Chlorine free & color safe; this oxy stain remover spray is Certified Safe for use on all carpet types and has the Seal of Approval from the Carpet and Rug Institute (CRI); will not leave residue that leaves your carpet feeling crunchy
  • Multi-Purpose – Use it to get out tough stains on carpet, upholstery, laundry, and all water-safe surfaces; use it as a mattress stain remover, upholstery cleaner, or couch stain remover
  • Safe - This carpet cleaner solution is safe to use around pets and children; non-aerosol and no hazardous propellants

The Ultimate Buying Guide: Choosing the Best Pet Stain Remover for Your Mattress

Accidents happen, especially with pets. When your furry friend has an “oopsie” on your mattress, you need a reliable cleaner. Finding the right pet stain remover is crucial for keeping your mattress fresh and healthy. This guide will help you pick the best product.

Key Features to Look For

A great mattress cleaner has several important features. You should look for these when shopping:

  • Enzymatic Action: This is the most important feature. Enzymes are tiny helpers that eat up the stain and the odor-causing bacteria. Look for cleaners labeled “Enzymatic.”
  • Odor Elimination: The cleaner must remove the smell, not just cover it up. Strong odors attract pets back to the same spot. Good cleaners destroy the odor source.
  • Safe Ingredients: Check the label. The formula must be safe for humans, pets, and your mattress fabric. Avoid harsh chemicals like bleach.
  • Fast-Drying Formula: Mattresses hold moisture easily. A quick-drying spray reduces the risk of mildew or mold growth inside the mattress.

Important Materials and Ingredients

What’s inside the bottle matters a lot. You want effective, yet gentle, ingredients.

Enzymes

These are biological cleaners. They break down the proteins in urine and feces. This process completely removes the stain and the smell.

Surfactants

These help the cleaner lift the stain from the fabric fibers. They are the soap-like part of the formula.

Natural vs. Chemical

Many top brands use plant-derived ingredients. These are often gentler on sensitive skin and smell better. However, always test a small spot first, even with natural products.

Factors That Improve or Reduce Product Quality

Not all stain removers work the same way. Some features make a product better.

Quality Boosters:
  • Deep Penetration: The cleaner must soak deep enough to reach the stain that soaked through the sheets and into the mattress padding.
  • Color Safety: High-quality cleaners will not bleach or damage the color of your mattress cover.
  • Residue-Free: The best formulas leave no sticky residue behind. Sticky spots attract more dirt later.
Quality Reducers:
  • Fragrance Overload: Products that just mask odors with very strong perfume are usually low quality. The smell fades, and the odor returns.
  • Too Much Water: Thin, watery solutions often lack the necessary cleaning power to tackle tough pet stains.
  • Harsh Chemicals: Ingredients like ammonia or chlorine bleach can damage mattress materials and pose a health risk.

User Experience and Use Cases

How you use the product greatly affects your results. Think about when and how you will use the cleaner.

Simple Accidents vs. Old Stains

For fresh, wet stains, act fast! Blot up as much liquid as you can before spraying. For older, set-in stains, you might need to let the enzymatic cleaner sit longer—sometimes for several hours—to fully break down the material.

Ease of Use

A spray bottle with an adjustable nozzle is convenient. You need to control the amount of liquid you apply. You do not want to soak the mattress completely.

Safety Testing

Always perform a spot test. Spray a small, hidden area of your mattress first. Wait ten minutes. If the color stays the same, you can safely use the product widely.


10 Frequently Asked Questions (FAQ) About Pet Stain Removers for Mattresses

Q: Will this cleaner really remove the smell?

A: Yes, if it uses enzymatic formulas. Enzymes destroy the odor-causing material, they don’t just cover it up.

Q: Can I use this on memory foam?

A: Most enzyme cleaners are safe for standard foam. However, never soak memory foam. Use a light spray and blot often.

Q: How long should the cleaner stay on the mattress?

A: For fresh stains, a few minutes is often enough. For tough, old stains, follow the bottle directions, but usually, you let it sit for 30 minutes to several hours.

Q: Is it safe to use bleach on pet stains?

A: No. Never use bleach on a mattress. Bleach can damage the fabric and the foam inside. Also, pet urine contains ammonia, and mixing it with bleach creates dangerous fumes.

Q: What if the stain is yellow?

A: Yellow is a common urine stain color. Enzymatic cleaners are specifically designed to target and remove these protein-based stains.

Q: Do I need to rinse the mattress after cleaning?

A: Most modern pet stain removers do not require rinsing. Rinsing adds excess water. Just blot the area with a dry towel after the cleaner works.

Q: How much liquid should I spray?

A: Use just enough to saturate the stain area, not the entire mattress. Too much moisture causes drying problems.

Q: Will this work on old, dried stains?

A: Yes, but you must use patience. Re-wet the area lightly and let the enzymes work for a long time to break down the dried material.

Q: Are these cleaners safe for my dog or cat?

A: Yes, once the area dries completely. The ingredients are usually safe for pets once the cleaning solution is gone.

Q: How can I prevent future stains?

A: Use a waterproof mattress protector. This barrier stops accidents from ever reaching your mattress foam.